Chemoselective reductions with sodium borohydride

Inactivation of Tetracycline with Sodium Borohydride.

Recently we reported on the rapid inactivation of tetracycline by use of cupric-morpholine complex (Kaplan, Lannon, and Buckwalter, J. Pharm. Sci., 64, 163, 1965). This degradation procedure is used as part of an assay technique for kanamycin in the presence of tetracycline. We have since found that sodium borohydride (Metal Hydrides Inc., Beverly, Mass.) can substitute for cupric-morpholine co...

The reduction of cozymase by sodium borohydride.

Cozymase (diphosphopyridine nucleotide, DPN) has been assayed by a variety of biochemical and chemical methods (1). Among the simplest procedures has been the determination of the light absorption of reduced DPN at 340 rnp after reduction by sodium hydrosulfite. Since special precautions are required to remove completely the excess reducing agent which absorbs in this region, it appeared advant...

High diastereoselectivity in borohydride reductions of coordinated imines.

Borohydride reduction of the imine groups in a pyruvate-derived cobalt(III) complex, (OC-6-33')-[Co(Aim(2)trien)](2)[ZnCl(4)], occurs with high diastereoselectivity. The major diastereoisomeric product, (OC-6-33'-ARSSR,CSRRS)-[Co(A(2)trien)]Cl has been isolated and crystallographically characterised. The results from base-induced isomerisation of the major isomer allow us to conclude that most ...

Bursting Dynamics in Molecular Hydrogen Generation via Sodium Borohydride Hydrolysis

The hydrolysis of borohydride salts is a promising process for the generation in situ of pure molecular hydrogen that can be used as an alternative fuel. One of the obstacles toward its concrete application in the realm of green energy resides in nonlinear behaviors of H2 delivery during the reaction development. In particular, we have recently shown that this system behaves like a chemical osc...

Quinine/Sodium Borohydride Complexes as Chiral Reductive Catalysts